Manager Chris Coleman could play Gareth Bale against Sweden in Wales’ final warm-up game before Euro 2016.
Joe Ledley, Joe Allen and Hal Robson-Kanu will all miss the trip to Stockholm on 5 June with injuries.
Coleman has dismissed concerns that Bale picked up an injury on route to winning the Champions League with Real Madrid and is not looking to wrap him in cotton wool ahead of France.
“We will see where Gareth is physically and mentally,” Coleman said.
“In the Champions League he went down with a bit of cramp and we were going ‘oh here we go’ but thankfully he was ok.
“We haven’t had Gareth since the Andorra game, which seems like a long time now.
“We will see how he is before we decide whether he starts in Sweden or whether he comes on. We will have a chat with him.”
Wales are preparing for a first major tournament in 58 years with injury concerns mounting.
Coleman is monitoring Ledley, who suffered a broken leg on 7 May, Liverpool’s Allen and Robson-Kanu with the trio now fighting to be fit for Wales’ opening game of the Euros on 11 June against Slovakia.
Wales also face England on 16 June and Russia on June 20.
“If we needed to really push the players we could, but we don’t need to do that,” Coleman told BBC Wales Sport.
“Hal and Joe won’t play in Sweden.
“We know what we are building for and what we are getting prepared for.
“The injured players’ rehab will be lined-up to get them training with us the week leading up to Slovakia.”
Emyr Huws and Wes Burns will travel to France to provide cover for Allen, Ledley and Robson-Kanu.
Coleman, who recently signed a new deal to stay as Wales boss, says Ledley is ahead of schedule in terms of his rehabilitation after including him in his 23 man squad and even thinks he could be fit for Wales’ group game.
“At the moment he is looking very good, he really is,” Coleman said.
“He’s a little bit further ahead than where we expected and physically he is looking fantastic, probably the best I have seen him looking.
“It is a credit to Joe that he is ahead of the curve for this type of injury.
We have between now and Slovakia and let’s hope we see an improvement and he keeps going the way he has been going and he will be available for us.
“It would be incredible and credit to him and credit to the medical team for getting him ready.”