Wreckage of EgyptAir flight MS804 has been found south of the Greek island of Karpathos, Egyptian aviation officials confirmed.
The Airbus A320 was en route from Paris to Cairo with 66 passengers and crew when it went down overnight.
Egyptian Vice-President Ahmed Adel told CNN the rescue operation was “turning into a search and recovery”.
Officials say the plane is more likely to have been brought down by a terrorist act than a technical fault.
It made two sharp turns and dropped more than 25,000ft (7,620m) before plunging into the Mediterranean Sea, Greek Defence Minister Panos Kammenos told reporters.
Search teams in the area have sighted debris from the plane, including life jackets.
“There have been finds south-east of Crete, inside the Cairo flight information area,” Greek army general staff spokesman Vassilis Beletsiotis told AFP news agency.
The search in seas south of the Greek island of Karpathos involves Greek and Egyptian naval forces, and the British Royal Air Force.
Sixty-six people were on board Flight MS804, most of them from Egypt and France. A Briton was among the passengers.
Of those on the plane, 56 were passengers, seven were crew members and three were security personnel.
Relatives of some of those on board are being flown from Paris Charles de Gaulle airport to Cairo.
Flight MS804 left Charles de Gaulle at 23:09 local time on Wednesday (21:09 GMT) and was scheduled to arrive in the Egyptian capital soon after 03:15 local time on Thursday.
Greek aviation officials say air traffic controllers spoke to the pilot when he entered Greek airspace and everything appeared normal.
They tried to contact him again at 02:27 Cairo time, as the plane was set to enter Egyptian airspace, but “despite repeated calls, the aircraft did not respond”. Two minutes later it vanished from radar.
Mr Kammenos said: “The picture we have at the moment on the accident as it emerges from the Greek air force operations centre is that the aircraft was approximately 10-15 miles inside the Egyptian FIR [flight information region] and at an altitude of 37,000 feet.
“It turned 90 degrees left and then a 360-degree turn toward the right, dropping from 37,000 to 15,000 feet and then it was lost at about 10,000 feet.”
Egyptian Aviation Minister Sherif Fathi said: “Let’s not try to jump to the side that is trying to identify this as a technical failure – on the contrary.
“If you analyse the situation properly, the possibility of having a different action, or having a terror attack, is higher than the possibility of having a technical [fault].”
people on board – 56 passengers, seven crew members and three security personnel
15 French citizens
1 from Britain, Canada, Belgium, Kuwait, Saudi Arabia, Algeria, Sudan, Chad and Portugal
Far too early to say: By Richard Westcott, BBC transport correspondent
An Egyptian aircraft disappearing without a Mayday signal is bound to raise the spectre of terrorism. But the truth is it is far too early to say why this plane vanished.
Whatever happened, it happened too quickly for the crew to raise the alarm.
Initially, the aircraft seemed to drop off the radar at 37,000 feet, suggesting a sudden break-up. It’s very rare for modern planes to simply break apart in mid air, but not impossible.
But then the Greek defence minister described the aircraft making sharp turns and dropping height quickly. Which suggests it was intact for longer.
Either way, it does not rule out either an accident, or something more sinister.
Even in the worst emergencies, pilots tell me they should have time to call for help, once they’ve got to grips with the problem. But not always.
French President Francois Hollande said: “We will draw conclusions when we have the truth about what happened.
“Whether it was an accident, or whether it was – and it’s something that is on our minds – terrorism.”
Flightradar24 listed details of the plane’s journey on Wednesday which showed it had flown from Asmara, in Eritrea, to Cairo, then on to Tunis, in Tunisia, before heading, via Cairo, to Paris.
Aviation analyst Alex Macheras told the BBC that Airbus A320s were regularly used for short-haul budget flights and had “an amazing safety record”.
In March, an EgyptAir plane was hijacked and diverted to Cyprus. The attacker later surrendered and all hostages were released.
If anyone is concerned about relatives or friends following the disappearance of the flight, they can call this free number provided by EgyptAir: +202 259 89320.
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