Motherwell could call for a postponement of Saturday’s match with Aberdeen if any more players are struck down by a virus at Fir Park.
Manager Mark McGhee was left with only six of his regular first-team players still training on Thursday.
“We had to shut down the club yesterday,” he said.
“If we had another three or four showing these symptoms and unable to train then it would leave me with no choice.”
Motherwell were forced to postpone an under-20s game against Celtic on Tuesday after the vast majority of the squad were laid low.
And a request to the Scottish Professional Football League would follow about the game against Aberdeen if the illness continues to spread among the first team.
“I might only have nine players including the entire under-20s,” said McGhee.
“I can’t go into a football match with eight or nine players.”
Motherwell already had Stephen Pearson ruled out with a punctured lung and broken ribs with fellow midfielder Keith Lasley a major doubt with a dead leg and defender Louis Laing still sidelined through injury.
“We had the entire under-20s wiped out by a virus,” said McGhee. “We had six of the first-team squad showing symptoms.
“At the moment, our count seems to be about 15, which includes two or three of the young boys who have never been involved at first-team level.
“So it’s looking pretty grim at the moment with Lasley, Pearson and Louis Laing all injured.”
Motherwell are hoping to consolidate their place in the top six following their 2-1 win over Dundee United on Friday, while the Dons will arrive aiming to continue their challenge with leaders Celtic at the top of the Premiership.
“Of the team who have been starting of late, we have probably got about six training this morning.
“If we turn up tomorrow with another three or four missing then we would be considering seriously whether the game can go ahead.
“But if I have nine or 10 of the ones that have been playing every week then I will be quite content to go into the game. I don’t want to go in with six though.”