Gareth Bale could miss Wales’ Euro 2016 warm-up game in Ukraine this month for the birth of his second child.
Emma Rhys-Jones, the Real Madrid forward’s partner, is expected to give birth in Spain over the Easter weekend.
That would be after the friendly against Northern Ireland in Cardiff on 24 March, but before the trip to Ukraine four days later.
Bale is set to be named in manager Chris Coleman’s squad for both matches, though.
If the former Tottenham forward was absent, it would add to Coleman’s lengthy absentee list as he prepares for Euro 2016, Wales’ first major finals since 1958.
Arsenal midfielder Aaron Ramsey, West Ham United defender James Collins and Wolves midfielder Dave Edwards will miss the two friendlies.
Ramsey is expected to be out for four weeks with a thigh injury he suffered during Arsenal’s FA Cup fifth-round replay win at Hull City on 8 March.
Collins is out with a hamstring injury while Edwards has had surgery on a fractured metatarsal and admits he faces a race to be fit for the finals in France.
Newcastle United defender Paul Dummett is also set to be ruled out with a hamstring injury.