Wasps ran in eight tries to stun Saracens and secure a bonus-point win over the Premiership leaders.
An unbelievable first eight minutes at Allianz Park saw Wasps’ Charles Piutau, Thomas Young and Dan Robson all cross.
Brad Barritt was driven over for Sarries before Nathan Hughes’ double gave Wasps a 31-16 half-time lead.
Jimmy Gopperth, Piutau and Robson added another three tries for Wasps as Sarries conceded the most points at home in their history.
The 64 points by Wasps was also the most they had ever scored away from home in the top flight as they moved up to fourth in the Premiership.
Relive the action as Wasps run riot at Saracens
Saracens had won nine successive games against Wasps, but the chance of a 10th was made almost impossible after the scintillating start from the visitors.
Piutau, playing alongside his brother Siale for the first time, dived over in the left corner, with Young then touching down following a fantastic burst from Josh Bassett and scrum-half Robson was given too much space to make it 19-0.
After Barritt reduced the arrears from the bottom of a driving maul, Hughes crashed over to secure the bonus point inside the opening half hour and then added another score shortly after.
There was no let-up in the relentless scoring after the break as the impressive Gopperth wriggled through before All Black Piutau added a seventh try for Wasps.
Gopperth, who scored 23 points in total, sent a penalty over from 50 metres to take Wasps past the 50-point mark in front of a silent home crowd.
Jim Hamilton bundled over for Saracens before Robson raced clear to complete one of the most remarkable victories in recent memory.
Saracens: Bosch; Ellery, Tompkins, Barritt, Wyles; Hodgson, Spencer; Barrington, Brits, Du Plessis, Hamilton, Hargreaves (capt), Rhodes, Burger, Vunisa
Replacements: Saunders, Gill, Lamositele, Smith, Fraser, Wigglesworth, Mordt, Ransom
Wasps: C Piutau; Wade, Daly, S Piutau, Bassett; Gopperth, Robson; McIntyre, Johnson, Cooper-Woolley, Cannon, Myall, Young, Smith (capt), Hughes
Replacements: Festuccia, Mullan, Swainston, Rowlands, Rieder, Stevenson, Miller
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