Gareth Anscombe is out of Wales’ opening 2016 Six Nations clash against Ireland in Dublin today.
The Cardiff Blues full-back has a hamstring strain and has been replaced by Liam Williams.
Scarlets’ Williams was omitted from Wales’ initial selection having played once since injuring a foot at the 2015 World Cup.
Wales opted not to bring replacement Rhys Priestland into the starting line-up.
Anscombe returned from his own ankle problem for Cardiff Blues in January, having also last played at the World Cup.
Wales went into the game with defence coach Shaun Edwards expecting an aerial barrage for their back three to deal with.
Scotland visit Cardiff on Sunday, 14 February in round two of the tournament and Wales say Anscombe is “expected to take part in full training” before that game.
Wales team: Liam Williams (Scarlets); George North (Northampton Saints), Jonathan Davies (ASM Clermont), Jamie Roberts (Harlequins), Tom James (Cardiff Blues); Dan Biggar (Ospreys), Gareth Davies (Scarlets); Rob Evans (Scarlets), Scott Baldwin (Ospreys), Samson Lee (Scarlets), Luke Charteris (Racing 92), Alun Wyn Jones (Ospreys), Sam Warburton (Cardiff Blues, Capt), Justin Tipuric (Ospreys), Taulupe Faletau (Newport Gwent Dragons).
Replacements: Ken Owens (Scarlets), Gethin Jenkins (Cardiff Blues), Tomas Francis (Exeter Chiefs), Bradley Davies (Wasps), Dan Lydiate (Ospreys), Lloyd Williams (Cardiff Blues), Rhys Priestland (Bath Rugby), Alex Cuthbert (Cardiff Blues).